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In comparison, the pancreatic islets isolated from the GLP-1R knock-out mice secreted 2 to 4-fold less insulin after incubation with GLP-1 WT, GLP-1 QMP, or Exendin-4, similar amounts to that measured for unfused WT albumin (Fig

Nat Med 27:10791087

A peer-reviewed development review explains that reversible albumin binding was used during the development of liraglutide and Semaglutide, with fatty-acid and linker chemistry selected to preserve GLP-1R potency while extending experimental exposure characteristics

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